Biochemistry

DEPARTMENT OF BIOCHEMISTRY

Biochemistry is the most progressive field of Medicine globally, trying to explain diseases at the molecular levels, evolve early diagnostic and novel therapeutic approaches with the aim of relieving patients of their pain and sufferings. The Department of Biochemistry in Govt. Medical College Amabikapur is working relentlessly with the same motto. The main purpose of our Department is to provide world class Medical education and hands on training in Medical Biochemistry and research to undergraduate students, which we try to achieve with the commitment of our dedicated team of faculty members, who being themselves trained in the premier institutes of our country, can not only guide, but also inspire students and nurture their zeal to learn.

Objectives of our Department

1. Describe the molecular and functional organization of a cell and list its subcellular components :
2. Delineate structure, function and inter-relationships of biomolecules and consequences of deviation from normal
3. Summarize the fundamental aspects of enzymology and clinical application wherein regulation of enzymatic activity is altered
4. Describe digestion and assimilation of nutrients and consequences of malnutrition
5. Integrate the various aspects of metabolism and their regulatory pathways
6. Explain the biochemical basis of inherited disorders with their associated sequelae
7. Describe mechanism involved in maintenance of body fluid and pH homeostasis
8. Outline the molecular mechanisms of gene expression and regulation, the principles of genetic engineering and their application in medicine
9. Summarize the molecular concepts of body defence and their application in medicine
10. Outline the biochemical basis of environmental health hazards, biochemical basis of cancer and carcinogenesis
11. Familiarize with the principles of various conventional and specialized laboratory investigations and instrumentation analysis and interpretation of a given data
12. The ability to suggest experiments to support theoretical concepts and clinical diagnosis

Infrastructure

The Department of Biochemistry has been developed with the elaborate infrastructure as prescribed by the Medical Council of India.

A) Demonstration Room

·  There is one separate Demonstration Rooms with sitting capacity of 100 students. It has a facility of Black Board & OHP.

B) Laboratory for Undergraduate

·  75 students at a time can perform practical work. Each seat is provided with separate glassware’s and laboratory tools. The laboratory is well equipped with all the facilities for biochemical investigations in blood, urine, CSF and gastric juice. Both qualitative and quantitative experiments are being carried out by UG students. There is a separate preparation room attached with UG laboratory.

C) Post Graduate Research Lab

·  There is a separate well equipped PG laboratory for post-graduates and Research students. Faculty members also carry out their Research Projects in PG Laboratory. PG Research lab is equipped with Spectro photometer, Electrophoresis, TLC, Homogenizer, Vaccum Pump, Flam Photometer etc.

D) Clinical Biochemistry Laboratory

·  The Clinical Biochemistry Lab is situated at Govt. District Hospital Ambikapur C.G. which is attached with Govt. Medical College Amabikapur. It is a well equipped Clinical Biochemistry Laboratory which caters to the need of patients of 300 bedded teaching hospital & rendering 24 hours biochemical investigative services. Routine biochemical investigations including Diabetic profile, liver function test, Kidney function test, Lipid profile, diagnostic enzymes and other specialized tests (Hb Electrophoresis) are being carried out on the request of clinicians for better diagnosis and management. Laboratory has both internal and external quality control.

E) Library cum Seminar

·  There is a Departmental Library-cum-Seminar room with sitting capacity of 25 students at a time and has good collection of books (113). Departmental seminars are being conducted regularly where latest researches in Biochemistry are being discussed.

F) Faculty Rooms

·  All the faculty members have their own rooms with Wi-Fi internet connections.

Practical

Part-I : Qualitative test (Carbohydrates, protein, Urine analysis)

Part-II : Quantitative test (Diabetic profile, Lipid profile, RFT, LFT, CSF etc.)

Part-III: Laboratory instrumentation ( pH meter, colorimeter, electrophoresis, TLC, etc)

Part-IV : Case report (Clinical case discussion)

Teaching- learning Methodology

·  1. Didactic lectures: 3 hours/ week.

·  2. Tutorials : 1.30 hours / week .

·  3. Demonstration and Practical : 7.30 hours /week

Text/Reference Books Recommended

·  1. Medical Biochemistry Ed. DM Vasudevan, Sreekumari S & Kanan Vaidyanathan

·  2. Lippincotts Biochemistry Ed Harvey

·  3. Text book of Biochemistry Pankaja Naik.

·  4. Principles of Biochemistry. Ed. Lehinger, Nelson and Cox. CBS Publishers and distributors.

·  5. Harper”s Biochemistry, Ed. R.K. Murray, D.K. Granner, P.A. Mayes and V.W. Rodwell. Appleton and Lange, Stamford, Connecticut

·  6. Tietz Textbook of Clinical Chemistry. Ed. Burtis and Ashwood. W.B. Saunders Company

Examination and marks distribution

·  Ist Terminal – 4th week of December – 1st week of January

·  Pre University – June – July

·  University (final) – July – august

Marks distribution

** Internal assessment will be calculated on the basis of PCT, Class test, Seminar, 1st Terminal, and Pre university Examination.

·Paper -1

·  Cell and subcellular Organelles, Acid Base Balance and pH, Body fluids, Water And Electrolyte Balance, Enzymes, Chemistry of Carbohydrates, Chemistry of Proteins, Chemistry of Lipids, Nutrition, Vitamins, Mineral Metabolism

Paper -2

·  Introduction To metabolism, Metabolism of Carbohydrates, Biological Oxidation, Metabolism of Aminoacids and Proteins, Metabolism of Lipids, Heme Synthesis and Breakdown, Chemistry And Metabolism of Nucleotides, Molecular Chemistry, Recombinant DNA Technology And Gene Therapy, Immunology, Free Radicals And Antioxidants, Detoxification And Xenobiotics, Organ Function Test, Radioisotopes in Medicine, Environmental Biochemistry, Advanced Biochemistry.

**syllabus of Paper I and Paper II subject to change year wise as per university guidelines.

·List of Faculty - 

List of Non-teaching staff.

Research Paper

• Evaluation of oxidative stress in rheumatoid arthritis.Rajesh Kumar Shrivastava, Vikas Gupta, Manish Kumar, Nita Garg.Indian Journal of Applied Research accepted for publication in December 2016 issue.
• Evaluation of inflammatory markers in Essential hypertension. Rajesh Kumar Shrivastava, Nita Garg.Indian Journal of Applied Research 2016;6(11):45- 46.
• A prospective study to see the effect of fenugreek seed powder as hypoglycaemic agent       on type II Diabetes Mellitus”. Rajesh Kumar Shrivastava, Mukesh Kumar Meena, Meena Varma, Susmit Kosta &  Ravindra Kumar.International Journal of Bioassay 2013; 2(10):1344-1348.
• Is TSH alone can be treated as diagnostic marker for Thyroid Disorders. Rajesh Kumar Shrivastava, Mukesh Kumar Meena, Meena Varma, Rajesh Kumar Jha, S. Kosta , Ravindra Kumar. Indian Journal of Applied Research 2013;3(11):361- 363.
• First Phase Insulin secretion, Insulin Sensitivity, Ghrelin, Glp-1 and Pyy level changes 72 hours after Sleev Gastrectomy  in obese Diabetic Patients: The Gastric hypothesis. Mukesh Kumar Meena, M.K.S. Shaikh, Meena Varma, Rajesh Kumar Shrivastava  &  Jain V.K.International Journal of Bioassay 2013; 2(11):1448-1452
• Comparative study of biochemical changes before & after 3 days of Bariatric Surgery in morbid obese patient. Mukesh Kumar Meena, M.K. Shaikh, Mohit Bhandari, Meena Varma, Rajesh Kumar  Shrivastava and Vivek Jain JARBS/2013/961(4).
• Comparative study of tobacco chewer & smokers as a risk factor for cardiovascular diseas. Dr. Rajesh Kumar Shrivastava, , Rajesh Kumar Jha, & Ravindra Kuma Indian Journal of Applied Research  January 2014 issue 2014;4(01):26-27